Ah, it would appear that I really am that good at communicating!!
Wife is neuro-typical (yay, I can remember the technical term!!), but history of bi-polar and OCD in her family. No Aspergers though, although she was the first one to pick it up in me. As to long term relationships, I have huge difficulties forming meaningful long term relationships with anyone, unless they actually get that I have no real/very limited capacity for emotional understanding - I can understand the concept of love, but as for actually feeling it? I know what the technical results are, but that's not really feeling it, that's a bit more computer-like analysis of it.
'Alone and misunderstood' tends to apply more socially, and especially professionally. My organisation is very 'client relationship' and 'organisation' based, whereas I am very technically creative and probably obsessed. I specialise in the analysis of words, storing of random information etc, and I'm very good at it, probably fuelled by my Aspergers. But I'm not so good at the understanding people part of it, and I find it a bit of a battle.
As for the bi-polar, that's more of an overlay. For about a quarter of the year, I am outside of what would be considered to be the normal mood range, be that elevated mood or depression. For about 4 weeks of that, I am either very high (I can do anything and I don't need any sleep to do it) or very low (nobody likes me, everybody hates me, I'm just going to eat worms, leading to a complete ambivolence about whether I am still alive at the end of the day). Thankfully suicide isn't something I have genuinely contemplated in a while. Its more difficult for my family than me, although its not really fun having a week of thinking I am a complete failure, usually personally rather than professionally, although it can get that bad. The whole not understanding people doesn't really help during the lows, and can make the whole 'everybody hates me' bit of things even more accute, sometimes leading to complete withdrawal.